Session recordings 2021

Session 1
SEssion 1 09:00-09:50 Session 1 09:55-10:45 Session 1 11:00-11:45

Session 2
Session 2 13:45-15:15

Session 3
Session 3 15:30-16:30

Session 4
Session 4 17:05-17:55

Session A
Always think of drug-drug Interactions Identifying and Understanding HIV Transmission The HIV reservoir don't forget about the brain The HIV reservoir First Find Then Clear

Session B
HIV Cure It Takes at least Two to Tango HIV Prevention It Ain't so Simple Long Term Complications As One Gets Older When PreP Fails MSM donate Blood and Kids with Poor Kidney Function Need

Session C
Curing HIV Science and Society Partnering HIV Medicine More than Meets the Eye HIV Prevention in the Time of COVID-19

Programme and Individual presentation recordings

09:00 - 11:50 Session 1: Extinguishing Both Fires: HIV and COVID-19

Session 1	Extinguishing Both Fires: HIV and COVID-19
Chairs: Tania Mudrikova (UMC Utrecht) & Rogier Sanders (Amsterdam UMC)
09:00 - 09:10	Welcome and introductions	Marit van Gils, Peter Reiss, Kim Sigaloff (Board stichting NCHIV)
09:10 - 09:30	The path to find an HIV vaccine	Glenda Gray (University of the Witwatersrand, South Africa)
09:30 - 09:50	Moderated Q&A
09:50 - 09:55	Short break
09:55 - 10:45	Distinct antibody lineages with multiple specificities achieve neutralization breadth in an HIV-1 infected elite neutralizer	Jelle van Schooten (Amsterdam UMC)
	People with HIV and suppressed viremia on ART are not at increased risk for acquiring SARS-CoV-2 infection	Myrthe Verburgh (Amsterdam UMC)
	Strong reduction in incidence of COVID-19-related hospitalization and death among people living with HIV in the Netherlands following the implementation of the national SARS-CoV-2 vaccination program	Ferdinand Wit (Stichting hiv monitoring)
	Cascade of care for people living with HIV in Aruba and Curaçao	Marlous Rodriguez (UMC Utrecht)
	Estimating the prevention potential of HIV infections in Amsterdam MSM, heterosexuals, and men and women with a migration background	Alexandra Blenkinsop (AIGHD; Imperial College London)
	Moderated Q&A
10:45 - 11:00	Break - Nigeria calling, Nwanneka Okere (AIGHD/Amsterdam UMC)
11:00 - 11:45	SHM 2021 Monitoring Report in the spotlight	Ard van Sighem, Colette Smit & Ferdinand Wit (SHM)
	Panel discussion 2021 NL Monitoring Report	Dinah Bons (Trans United Europe) Judith Branger (NVHB kwaliteitscommissie) Wilma Brokking (DC klinieken A'dam) Maria Prins (GGD A'dam) Moderator: Marc van der Valk (SHM)
11:45 - 11:50	Short break - Australia calling, Jori Symons (UMCU)
11:50 - 12:10	Parallel spotlight sessions followed by a moderated Q&A (see separate dropdown session A)
12:10 - 12:15	Short break - Kenya calling, Makobu Kimani (AIGHD/Amsterdam UMC & KEMRI Wellcome Trust, Kilifi)
12:15 - 12:35	Parallel spotlight sessions followed by a moderated Q&A (see separate dropdown session B)

11:50 - 12:10 Parallel spotlight session A


Identifying and Understanding HIV Transmission
	Availability and accessibility of HIV self-tests and self-sample kits at community pharmacies in the Netherlands	Eline op de Coul (RIVM)
	Effectiveness of directly assisted and unassisted HIV self-testing as an alternative mode of HIV screening for individuals from migrant communities at AHF Checkpoint Amsterdam during the COVID-19 pandemic	Anna Żakowicz (AHF Europe)
	Specific vaginal microbiota enhance HIV-1 transmission	Leanne Helgers (Amsterdam UMC)
	Moderated Q&A	Silke David (RIVM)
The HIV Reservoir: First Find, Then Clear
	A novel flow cytometry-fluorescent in situ hybridization approach to detect transcriptionally latent and transcriptionally active HIV-1 in CD4+ T cells from people living with HIV	Shirley Man (Amsterdam UMC)
	Using the CRISPR-Cas9 system to cure cells from HIV and at the same time prevent super-infection by new HIV strains	Mouraya Hussein (Amsterdam UMC)
	A Nanobody-Based HIV-1 Engager (Nano-HIVE) Antibody for NK Cell-Mediated Clearance of HIV-1 Infected Cells	Jeffrey Umotoy (Amsterdam UMC)
	Moderated Q&A	Marit van Gils (Amsterdam UMC)
The HIV reservoir; don’t forget about the brain
	People living with HIV using cART have higher percentages of circulating CCR5+CD8+ T cells and lower percentages of CCR5+ regulatory T cells compared to healthy controls	Louise van Eekeren (Radboudumc)
	Investigating HIV neuropathogenesis using human monocyte-derived microglia culture model	Lavina Gharu (UMC Utrecht)
	Improving Fc-effector function of anti-HIV-1 bNAbs by glycoengineering	Steven de Taeye (Amsterdam UMC)
	Moderated Q&A	Casper Rokx (Erasmus MC)
Always Think Of Drug-drug Interactions
	Unexpected high incidence of low dolutegravir trough levels in patients treated with rifampin for TB/HIV co-infection, despite dolutegravir dose adjustment	David Burger (Radboudumc)
	Tenofovir alafenamide concentrations are reduced by half in pregnant women living with HIV: data from the PANNA Network	Angela Colbers (Radboudumc)
	Dexamethasone is a dose-dependent perpetrator of drug-drug interactions: Implications for use in people living with HIV	Tom Jacobs (Radboudumc)
	Moderated Q&A	Kim Sigaloff (Amsterdam UMC)

12:15 - 12:35 Parallel spotlight session B


HIV Prevention: It Ain’t So Simple
	Improving Prevalence and Risk Estimates of MSM Living with HIV in the Netherlands: A Public Health Service Level Small Area Estimation Modelling Analysis with a Bayesian Approach	Haoyi Wang (Maastricht University)
	Trajectories of PrEP use among men who have sex with men: a pooled analysis of two observational cohort studies	Vita Jongen (GGD Amsterdam)
	Biannual versus quarterly bacterial STI screening of PrEP users in Amsterdam, the Netherlands	Hanne Zimmermann (GGD Amsterdam; Maastricht University)
	Moderated Q&A	Silke David (RIVM)
HIV Cure: It Takes At Least Two To Tango
	Human microglial culture models to investigate HIV neuropathogenesis	Stephanie Gumbs (UMC Utrecht)
	Fusion of a human IgG1 to broadly neutralizing anti-HIV-1 nanobodies results in improved neutralization potency and the ability to mediate Fc effector functions	Angela Schriek (Amsterdam UMC)
	Community engagement in HIV cure research efforts: Exploring perspectives on meaningful involvement, whether a cure will change stigma, and the importance of language amongst people with HIV	Tamika Marcos (Maastricht University)
	Moderated Q&A	Marit van Gils (Amsterdam UMC)
Long Term Complications: As One Gets Older
	A longitudinal analysis of cerebral blood flow in perinatally HIV infected adolescents as compared to matched healthy controls	Jason van Genderen (Emma Children's Hospital)
	Long term trends of coagulation parameters in people living with HIV-1 treated with combined antiretroviral therapy	Soerajja Bhoelan (UMC Groningen)
	Long term trends of coagulation parameters in people living with HIV-1 treated with combined antiretroviral therapy	Piter Oosterhof (OLVG)
	Moderated Q&A	Casper Rokx (Erasmus MC)
When PreP Fails, MSM Donate Blood and Kids with Poor Kidney Function Need 3TC
	Primary HIV-1-infection with emtricitabine/tenofovir disoproxil resistant strain in a man who has sex with men (MSM) on pre-exposure prophylaxis (PrEP) despite excellent self-reported adherence for multiple years: a case report	Jeffrey Koole (GGD Amsterdam)
	Changing blood donor selection policies regarding men-having-sex-with-men (MSM): A potential for HIV stigma reduction?	Kennedy D'Abreu de Paulo (Maastricht University)
	Using PBPK modelling to estimate lamivudine exposure when applying dose reductions for children with abnormal kidney function	Thomas Nieuwenstein (Radboudumc)
	Moderated Q&A	Kim Sigaloff (Amsterdam UMC)

12:35 - 13:35 Lunch session


Gilead
12:35 - 12:50	ART of Gilead: past, present and future	Joel Gallant (MD, MPH, Executive Director of Medical Affairs at Gilead Sciences)
12:50 - 13:00	Q&A

MSD
TBA

ViiV
12:35 -12:40	Introduction	Bart Lammertink (Country Medical Lead ViiV Healthcare Netherlands)
12:40 - 12:50	ViiV’s commitment to the global fight against HIV	Interview with Deborah Waterhouse, Chief Executive Officer (CEO) ViiV Healthcare
12:50 - 13:25	Samenwerking tussen zorgverleners en de farmaceutische industrie: nuttig, noodzakelijk kwaad of nooit doen? (This session will be in Dutch)	De achtergrond, inhoud en praktische toepassing van de CGR Gedragscode, over samenwerking tussen zorgverleners en farmaceutische industrie, met Marloes Meddens-Bakker (advocaat)

13:35 - 15:30 Session 2: Promises and Barriers Toward an HIV Cure

Session 2	Promises and Barriers Toward an HIV Cure
Chairs: Godelieve de Bree (Amsterdam UMC) & Jori Symons (UMC Utrecht) & TBA
13:35 - 13:40	Intro
13:40 - 14:00	The latest insights on the HIV viral reservoir: implications for curing HIV	Nicolas Chomont (University of Montreal, Canada)
14:00 - 14:20	Moderated Q&A
14:20 - 14:25	Short break - ,Zimbabwe calling, Tom Jacobs (Radboudumc)
14:25 - 15:15	Defining HIV-1’s doorway into the intestinal mucosa using an advanced human primary gut-epithelial-immune cell co-culture organoid model	Anusca Rader (Amsterdam UMC)
	Continuous decline of intact proviral DNA after two decades of antiretroviral therapy	Marieke Nühn (UMC Utrecht)
	Identifying host genetic determinants of HIV-1 reservoir markers reveals PTDSS2, RNH1 and IRF7 as potential modifying factors in HIV-1 patients	Marc Blaauw (Radboudumc)
	Genetic variation in autophagy machinery is associated with enhanced antiviral T-cell immunity and reduced T-cell exhaustion signatures in HIV-1 infected individuals	Renee Schreurs (Amsterdam UMC)
	Trends in HIV Stigma Experienced by People with HIV in the Netherlands: A Comparison of Cross-sectional Surveys Over Time	Sarah Stutterheim (Maastricht University)
	Moderated Q&A
	Break

15:30 - 17:05 Session 3: The Changing Spectrum of ART

Session 3	The Changing Spectrum of ART
15:30 - 15:45	Providing ART: a Personal Reflection	Sven Danner
15:45 - 16:25	Long-acting ART: a paradigm shift? (panel discussion)	Natasja van Holten (LUMC) Piter Oosterhof (OLVG) Cissy Kityo (JCRC, Kampala, Ugana) Edwin Oraki (perspective from a person living with HIV) Moderators: Bertus Tempert (Hiv vereniging) & Jet Gisolf (Rijnstate)
16:25 - 16:30	Short break - Ukraine calling, Marta Vasylyev (ErasmusMC & Astar Medical Center, Lviv)
16:30 - 16:50	Parallel spotlight sessions followed by a moderated Q&A (see separate dropdown session C)
16:50 - 16:55	Short break - Zimbabwe/Uganda/Zambia/S Africa calling, Hylke Waalewijn (Radboudumc)
16:55 - 17:05	The Joep Lange and Jacqueline van Tongeren Young Investigator Award Ceremony

16:30 - 17:05 Parallel spotlight session C


HIV Prevention In The Time Of COVID-19
	Subgroups of sexual behaviour in men who have sex with men using pre-exposure prophylaxis in the Netherlands: transitions over time, determinants of transitions, and STI positivity rates	Daphne van Wees (RIVM)
	Effects of three phases of COVID-19 restrictions on sexual healthcare use, pre-exposure prophylaxis use and sexually transmitted infection incidence among men who have sex with men in Amsterdam, the Netherlands	Feline de la Court (GGD Amsterdam)
	Reduction in the magnitude of COVID-19-associated changes in sexual activity and disruption in HIV/STI testing or PrEP use among MSM responding to the 2nd COVID-19, sex and intimacy survey	Philippe Adam (IPSR Utrecht; UNSW Sydney)
	Moderated Q&A	Janneke Heijne (RIVM)
Curing HIV: Science and Society Partnering
	NCHIV21_Characterization of the HIV-1 subtype C reservoir during ART in South-African men and womenS28_2021-11-10_16-21	Ninee Buchholtz (UMC Utrecht)
	Extinction of all infectious HIV in cell culture by the CRISPR-Cas12b system	Minghui Fan (Amsterdam UMC)
	Social engagement of people with HIV in HIV cure research: awareness, importance and meaning of HIV cure	Maaike Noorman (Utrecht University)
	Moderated Q&A	Neeltje Kootstra (Amsterdam UMC)
HIV Medicine: More Than Meets The Eye
	High rates of diffusion impairment after Pneumocystis jirovecii pneumonia in people living with HIV: a retrospective cross-sectional study	Patrick Oomen (UMC Utrecht)
	Retinal structure in relation to brain function in perinatally HIV-infected adolescents: a longitudinal and cross-sectional assessment	Charissa Verkade (Emma Children's Hospital)
	Preference for non-daily art is associated with ART-related emotional, psychosocial, physical and adherence challenges among people living with HIV in the Netherlands	Reon van Dyk (ViiV Healthcare)
	Moderated Q&A	Wouter Bierman (UMC Groningen)

17:05 - 18:00 Session 4: 40 Years of Aids

Session 4	40 Years of Aids
	Interviewer Antoinnette Scheulderman (o.m. Volkskrant magazine) gaat in gesprek met Anne van de Laar (ervaringsdeskundige), Gloria Summerville (oprichtster Stichting Het Rode Lint), Mark Vermeulen (directeur Aidsfonds) en Peter Reiss (internist-onderzoeker). This session will be held in Dutch
17:55 - 18:00	Closing